Suicide attacker kills at least 20 in Damascus
Dozens more were injured, including children, the ministry said in a letter to the UN Security Council, according to state media.
Syria's Health Minister Nizar Yazigi said injuries ranged from minor to severe, state media reported.
Authorities had been pursuing three cars and were able to intercept two and destroy them, state media said.
As they closed in on the third car near the city's Al-Tahrir Square, the suicide bomber on board detonated it.